Titlebook: Chromosome Architecture; Methods and Protocol Mark C. Leake Book 2016 Springer Science+Business Media New York 2016 dynamic architecture.ch

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Thomas Reid,Ludwig Wittgensteinderstanding this organization requires the integration of many data types and experimental results. Here we describe the approach of integrating genome-wide protein–DNA binding data to determine chromatin states. To investigate spatial aspects of genome organization, we present a detailed descriptio

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https://doi.org/10.1007/978-3-663-12339-2cells and by detecting cell-scattered light their number and relative size can be measured as they pass through the beam. Labeling of molecules, usually via a fluorescent reporter, allows the amount of these molecules per cell to be quantified. DNA content can be estimated using this approach and he

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Studies in Computational Intelligencets during the cell cycle, for example, to reliably segregate daughter chromosomes. More recently, various labs have begun investigating the short-time dynamics (displacements during time intervals of 0.1–100 s), which one hopes to link to structure, in analogy to “microrheology” approaches applied s

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Jeremy Grech,Mark Bugeja,Dylan Seychellrepair are driven by the mechanisms by which a functional nuclear protein finds its substrate in the nucleus. Single-particle tracking (SPT) is a method to quantify fluorescent molecules dynamics from the tracks of the single molecules recorded by high-resolution microscopes. SPT offers direct obser