Titlebook: Chromosomal Instability in Cancer Cells; B. Michael Ghadimi,Thomas Ried Book 2015 Springer International Publishing Switzerland 2015 Aneup

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Telomere Dysfunction, Chromosomal Instability and Cancer, and to the initiation of tumors, however, initiated tumors need to reactivate telomerase in order to stabilize chromosomes and to gain immortal growth capacity. In this review, we summarize current knowledge on the role of telomeres in the maintenance of chromosomal stability and carcinogenesis.

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Patterns of Chromosomal Aberrations in Solid Tumors,ecular characterization of cytogenetic abnormalities has provided insights into the mechanisms of tumorigenesis and has, in a few instances, led to the clinical implementation of effective diagnostic and prognostic tools, as well as treatment strategies that target a specific genetic abnormality.

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Yeast as Models of Mitotic Fidelity,and physiology. This chapter focuses on the current understanding of how the yeast . . responds to the acquisition of extra chromosomes and highlights how studies in aneuploid yeasts provide insights onto the effects of aneuploidy in human cells.

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0080-0015 f cancer patients.Written by acknowledged experts in the fie.This issue of .Recent Results in Cancer Research. presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer

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DNA Repair and Chromosomal Translocations,y. The non-homologous end-joining repair (NHEJ) pathways seem to play the major role in the generation of chromosomal translocations. The “l(fā)andscape” of chromosomal translocation identified in malignancies is largely due to selection processes which operate on the growth advantages conveyed to the c

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malign