Titlebook: Chromosomal Alterations; Origin and Significa Günter Obe,Adayapalam T. Natarajan Book 1994 Springer-Verlag Berlin Heidelberg 1994 Chromosom

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ered. .Further, topics such as automation of aberration scoring, problems associated with using chromosomal aberrations and micronuclei in population monitoring and the importance of chromosomal aberration assays in mutagenicity testing of chemicals are included.978-3-642-78889-5978-3-642-78887-1

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https://doi.org/10.1057/9781137507037hile the origin of classical chromosome aberrations e.g. inversions or translocations is mostly well described by the “breakage and fusion” theory (Muller 1938), no such general theory applies to HSRs. We have to choose among several hypotheses (see Windle and Wahl 1992).

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https://doi.org/10.1007/978-3-658-35757-3lly assumed that cells would sustain the same amount of initial damage per unit amount of DNA at all times during the cell cycle, but the efficiency with which dsb are repaired would affect the formation of chromosomal aberrations (deletions or exchanges) and determine relative radiosensitivity (Bender et al. 1974).

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