Titlebook: Cholinergic Basis for Alzheimer Therapy; Robert Becker,Ezio Giacobini Book 1991 Springer Science+Business Media New York 1991 Alzheimer‘‘s

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Cholinesterases in Human Degenerative Diseasesese disorders is Alzheimer’s disease (AD). In AD there is a degeneration of projections from the cholinergic basal forebrain to the neocortex and hippocampus resulting in a loss of cell bodies in the basal forebrain and reduced cortical choline acetyltransferase and acetylcholinesterase (AChE) enzym

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Structure of the Acetylcholinesterase Gene: Regulation of Its Expressiontion may prove palliative in the treatment of Alzheimer’s disease. Use of selective acetylcholinesterase (AChE) inhibitors which are retained within the central nervous system is one widely considered approach. An alternative approach would be regulation of expression of proteins critical to choline

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Presynaptic Cholinergic Mechanisms in Human Cerebral Cortex of Adult and Aged Patients in rat brain (Molenaar and Polak, 1970; Marchi et al., 1981). A muscarinic receptor mediated mechanism similar to that present in the rodent was proposed to exist, on the basis of indirect evidence, also in human brain (Marek et al., 1982; Nordstrom et al., 1982; Nilsson et al., 1987).

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Nicotinic Acetylcholine Receptors in the Human Nervous Systemromuscular junction, in autonomic ganglia and in several areas of the brain. The activation of AChR by the acetylcholine (ACh) released from nerve terminals induces an influx of cations, mainly Na. ions, through the cell membrane, consequently depolarizing the target cell.

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