Titlebook: Cholesterol Transporters of the START Domain Protein Family in Health and Disease; START Proteins - Str Barbara J. Clark,Douglas‘M. Stocco

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,Abkürzungen, Bezeichnungen und Symbole,al and gonads following tropic hormone stimulation. StAR synthesis is required for the first and rate-limiting step in steroid hormone biosynthesis, cholesterol transport into mitochondria. It was a long journey to finding the acute regulator of steroidogenesis, and this chapter provides a historica

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https://doi.org/10.1007/978-3-642-81608-6ids that binds a broad variety of lipids and sterols. START domain proteins have various expression patterns and cellular localizations and are involved in lipid metabolism, lipid transfer, and cell signalling. The α-helix/β-grip tertiary structure delimits an internal cavity forming the binding sit

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,Hydrostatische Anlagen — Stand der Technik,chanisms by which cholesterol is delivered to cellular destinations remains under investigation. Steroidogenic cells must transport large amounts of cholesterol to, and then into, the mitochondria, where the cholesterol side-chain cleavage enzyme, P450scc, resides. P450scc is the first enzyme in ste

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Struktursynthese hydrostatischer Anlagen,which share ~?30?% amino acid identity with each other, ~?20?% with the StAR/STARD1 and STARD3/metastatic lymph node clone 64 (MLN64) START domains, and ~?15?% with other START domains. All three have no other protein domains besides START. Since their initial discovery, they were proposed to serve

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https://doi.org/10.1007/978-3-642-81608-6o maintain the proper sterol and lipid distribution. The steroidogenic acute regulatory protein-related lipid transfer (START) domain family are defined by a conserved 210 amino acid sequence that folds into an α/β helix-grip structure containing a hydrophobic pocket for ligand binding. The mammalia

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