| 書目名稱 | Cholesteatoma and Anterior Tympanotomy | | 編輯 | Tamotsu Morimitsu | | 視頻video | http://file.papertrans.cn/227/226152/226152.mp4 | | 圖書封面 |  | | 描述 | Acquired aural cholesteatoma poses a unique procedural dilemma with regard to pathogenetic research and theory building. Because cholesteatoma spontane- ously occurs only in the poorly pneumatized human ear, its pathogenesis is specific to humans. Nonetheless, because of the ethical questions surrounding human experimentation, pathogenetic study has almost exclusively involved nonhuman subjects. Indeed, attempts have failed in almost all animal expe- riments except with the gerbil, and even here experimental designs have been improbable compared with human cholesteatoma. Cholesteatoma in the gerbil is useful, therefore, only for the study of pathology and not for human pathogenesis. I hold that the pathogenesis of cholesteatoma will be understood by studying the cholesteatomatous ear, that is, the malpneumatized ear of the human. The anatomical difference between the normal and malpneumatized ear is a probable cause of cholesteatoma. This difference may be found clinically in facial nerve decompression and cholesteatoma surgery, as, for example, facial nerve palsy occurs usually in the normal, well-pneumatized ear. Of course, conventional animal experimentation will not confirm thi | | 出版日期 | Book 1997 | | 關鍵詞 | anterior tympanotomy; cholesteatoma; ear; otorhinolaryngology; pathogenesis; supratubal recess; tympanic d | | 版次 | 1 | | doi | https://doi.org/10.1007/978-4-431-68439-8 | | isbn_softcover | 978-4-431-68441-1 | | isbn_ebook | 978-4-431-68439-8 | | copyright | Springer-Verlag Tokyo 1997 |
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