Titlebook: Cholecystokinin Antagonists in Gastroenterology; Basic and Clinical S Guido Adler,Christoph Beglinger Book 1991 Springer-Verlag Berlin Heid

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Rechenübungen zur angewandten Elektronikuish CCK receptor subtypes or have higher potency, will be developed, probably from one of the five different classes currently described. In this chapter the results of in vitro studies with each of the different classes of CCK receptor antagonists are reviewed.

結(jié)合

Biological Actions of CCK in the Gastrointestinal Tractthe potential effects of CCK and continue to do so today, but they do not define which of these many responses of the gastrointestinal tract to exogenous stimulation are in fact regulated by endogenous CCK. Table 1 summarizes many of the reported actions of exogenous CCK.

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pancreas

Servile

Biochemistry of CCKle advances in our understanding of the biochemistry of this substance that have taken place over the last 20 years. It also marked the culmination of what can now been seen as the pioneering phase in the development of our ideas of the hormonal regulation of digestion in the small intestine. Mutt a

SNEER

The Morphological Localization of Cholecystokinin and Its Binding Sites in the Diffuse Neuroendocrin major hindrance to the investigation of CCK localization has been the fact that its C-terminal pentapeptide is identical to that of another major gut peptide, gastrin. These amino acids are responsible for the biological activity of the peptides, with differential specificity of action being confer

CARE

Biological Actions of CCK in the Gastrointestinal Tractve years later, it was shown that CCK was chemically identical with pancreozymin [2], another putative hormone thought to cause pancreatic enzyme secretion in response to fat and protein in the intestine [3]. In the years since the discoveries of these two major actions, CCK has been found to have m

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Biological Actions of CCK in the Central Nervous System presence of gastrin-like immunoreactivity in mammalian brain, and subsequent studies indicate that the majority of this immunoreactivity could be attributed to CCK. Although a large peptide containing 58 amino acid (CCK58) is the major circulating form of CCK in humans and dogs [21,23], the predomi

Polydipsia

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Characterization of MK-329tion product from Aspergillus alliaceus [1], asperlicin. Its lack of oral activity and the need for greater potency stimulated the design of improved antagonists. On the basis of structural relationships between asperlicin and the molecules diazepam and D-tryptophan, an indolylmethyl benzodiazepine