Titlebook: Chemotherapy; Frederick F. Becker Book 1977 Plenum Press, New York 1977 brain tumors.breast cancer.cancer.cell.chemotherapy.classification

Somber

Diffuse Reflectance from TLC Layers,ucleic acids. For instance, agents such as actinomycin or the anthracyclines, adriamycin and daunomycin, bind DNA ., but this binding is not associated with DNA-strand breakage, at least under the conditions that have been used; the incubation of these agents with intact cells, however, is associate

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https://doi.org/10.1007/978-3-642-10883-9tly their accessibility to substrates. This very macromolecular nature enables enzymes to demonstrate a high degree of substrate specificity that can be very useful in restricting their cytotoxicity toward specific tissues, e.g., asparaginase therapy of asparagine-dependent leukemia cells.

cocoon

Factors That Influence the Therapeutic Responsecal trial of a chemotherapeutic agent took place in 1942, when nitrogen mustard was given to a patient with advanced lymphosarcoma (Goodman .., 1946). A dramatic but unfortunately brief tumor response was achieved in this patient. Later in that same decade, Sidney Farber observed what he termed an “

Muscularis

Applications of Cell Kinetic Techniques to Human Malignanciesiew data that are available for specific human neoplasms. The chapter includes information that influences the planning of treatment as well as information that reflects the response to therapy. A variety of techniques, both . and ., that have been developed in animal tumor systems are now being app

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gentle

MAPLE

Adjunctive Chemotherapyic agents. Many of the drugs have been used effectively in hematologic neoplasms, and with their use, complete remission and survival rates in childhood leukemia and in Hodgkin’s disease and other lymphomas have increased very significantly. Several of the solid tumors such as sarcomas, breast carci

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Principles of Combination Chemotherapyme children with acute leukemia. Remarkable as these early remissions were, it soon became apparent that with the exception of methotrexate-induced cure of choriocarcinoma (Li ..,1956) (and later cyclophosphamide-induced cure of Burkitt’s lymphoma) (Nkrumah and Perkins, 1976; Ziegler .., 1973), sing

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Intraarterial Chemotherapyudicious use of surgery and irradiation (external beam and isotope implantation) has traditionally occupied an important place in the systematic management of patients with advanced malignancy. Systemic chemotherapy can also be used to treat predominantly regional disease, and the intraarterial deli

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Treatment of Malignant Disease in Closed Spacess in management. Its occurrence, while a manifestation of systemic disease, does not bear a relationship to prognosis, except perhaps in malignant lymphoma. While removal may be necessary for symptomatic relief, repeated thoracentesis may have significant complications. For this reason, ideal treatm