Titlebook: Chemistry and Safety of Acrylamide in Food; Mendel Friedman,Don Mottram Conference proceedings 2005 The Editor(s) (if applicable) and The

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Acrylamide in Food: The Discovery and Its Implications,esult of systematic research and relevant developments in methodology over decades, as well as a chain of certain coincidences. The present paper describes the scientific approach, investigations and events leading to the discovery of the formation of AA during cooking of foods. In addition, related

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Acrylamide Neurotoxicity: Neurological, Morhological and Molecular Endpoints in Animal Models,lthough experimental animal studies have implicated carcinogenicity and reproductive toxicity as possible consequences of exposure, neurotoxicity is the only outcome identified by epidemiological studies of occupationally exposed human populations. Neurotoxicity in both humans and laboratory animals

Muscularis

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Mechanisms of Acrylamide Induced Rodent Carcinogenesis,ause several toxic effects and has the potential for human exposure either through the environment or from occupational exposure. Recently, additional concern for the potential toxicity of acrylamide in humans has arisen with the finding of acrylamide formation in some processed foods. It has been e

Melanoma

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Pilot Study on the Impact of Potato Chips Consumption on Biomarkers of Acrylamide Exposure,in adducts of acrylamide and its primary metabolite glycidamide as biomarkers. Little is known about the impact of acrylamide in food on biomarkers of acrylamide exposure. Therefore, CDC is conducting a feeding study to investigate the effect of consumption of endogenous acrylamide in food on biomar

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LC/MS/MS Method for the Analysis of Acrylamide and Glycidamide Hemoglobin Adducts,these biomarkers in blood have been described previously. These methods were developed to analyze small numbers of samples, not the high sample throughput that is needed in population screening. Obtaining data on exposure of the US population to acrylamide through food and other sources is important

fructose

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Kinetic and Mechanistic Data Needs for a Human Phsiologically Based Pharmacokinetic (PBPK) Model foinformation. Despite gaps and limitations to the database, model parameters have been estimated to provide a relatively consistent description of the kinetics of acrylamide and glycidamide using a single set of values (with minor adjustments in some cases). Future kinetic and mechanistic studies wil

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Studies of the Influence of Certain Enzymes on the Detoxification of Acrylamide and Glycidamide inmicals, such as acrylamide, as a result of such genetic polymorphisms might affect health-risk assessments. Detoxification by, for example, conjugation with glutathione (GSH) will decrease the concentration. The dose of the compound and enzymes that enhance the conjugation with GSH will increase the