Titlebook: Chemical Mixtures and Combined Chemical and Nonchemical Stressors; Exposure, Toxicity, Cynthia V. Rider,Jane Ellen Simmons Book 2018 Sprin

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Adverse Outcome Pathways to Support the Assessment of Chemical Mixturesconsidering mechanistic data in a mixtures assessment. The use of this concept provides a means to allow more specificity when deciding whether to use dose addition, independent action or integrated addition risk assessment methodologies. Furthermore, AOPs enable novel approaches for determining che

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Dose-Response Modelingoice of functional form used to describe how the mean response changes as dose increases as well as the evaluation of how well the chosen form fits the data at hand. The chapter also points out that proper modeling of the variability inherent in the structure of the data is crucial to efficient stat

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Mixture Experimental Designtatistical mixture designs such as the isobologram and the fixed ratio ray. General considerations are provided that will aid in the development of both experimental design and analysis strategies that address the question(s) being asked.

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Chemical Mixtures and Combined Chemical and Nonchemical StressorsExposure, Toxicity,

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