Titlebook: Chemical Genomics; Reviews and Protocol Edward D. Zanders Book 2005 Humana Press 2005 Escherichia coli.Microarray.Proteomics.genetic inform

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,Wettbewerb Kohle — Wasserkraft,hich the purification and immobilization procedures are combined into a single step, dramatically simplifying the array fabrication process. We illustrate this approach by reference to the creation of an array of p53 variants, and discuss methods for assay and data analysis on such arrays.

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Beileitung und Pumpspeicherung,d surface via a covalent bond. In the second method, peptides or small molecules are first conjugated to a macromolecular scaffold. The final ligand-scaffold conjugates are then spotted and adsorbed onto the solid surface. Three different assay methods to screen such chemical microarrays are described.

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Chemistry for Chemical Genomicsnthesis strategies for the application of small molecules as tools for chemical genomics. Examples for different successful chemical-genomics strategies include the selection of diverse drug-like molecules, target family—focused compound libraries, natural-product chemistry, and diversity-oriented synthesis.

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Fabrication of Protein Function Microarrays for Systems-Oriented Proteomic Analysishich the purification and immobilization procedures are combined into a single step, dramatically simplifying the array fabrication process. We illustrate this approach by reference to the creation of an array of p53 variants, and discuss methods for assay and data analysis on such arrays.

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Peptide and Small-Molecule Microarraysd surface via a covalent bond. In the second method, peptides or small molecules are first conjugated to a macromolecular scaffold. The final ligand-scaffold conjugates are then spotted and adsorbed onto the solid surface. Three different assay methods to screen such chemical microarrays are described.

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