Titlebook: Chemical Epigenetics; Antonello Mai Book 2020 Springer Nature Switzerland AG 2020 Epigenetic targets.HDAC inhibitors.cyclic peptides.SIRT

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Lysine Methyltransferases and Their Inhibitors,ing body of literature is indicating that lysine methyltransferases (KMTs) play a crucial role for transcriptional regulation and are involved in cancer and various other human diseases, thus being of high interest as potential therapeutic targets..In this book chapter, we highlight the discovery, c

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Lysine-Specific Histone Demethylases 1/2 (LSD1/2) and Their Inhibitors,une response, and signal transduction. Histone methylation is closely associated with the oncogenesis and proliferation of cancer cells, and its alteration has been identified in many cancer cells. In addition, histone methylation is involved in such non-cancerous diseases as globin disorders and ne

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Inhibitors of JmjC-Containing Histone Demethylases,hylation and dysregulation of KDMs have been linked to multiple diseases, and KDMs are emerging as promising therapeutic targets. This chapter provides an overview of JmjC-domain-containing KDMs (JmjC-KDMs), with a particular focus on recent advances in JmjC-KDM inhibitor development from a structur

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Methyl-Readers and Inhibitors,mall-molecule intervention. Within this book chapter, the biological role and the associated development of potent small molecules inhibiting the protein-protein interaction of methyllysine readers (Tudor, malignant brain tumor, chromo-, and PHD domain) will be discussed. The druggability of these r