Titlebook: Checkpoint Responses in Cancer Therapy; Wei Dai Book 2008 Humana Press 2008 DNA.apoptosis.biotechnology.cancer.cancer research.cancer ther

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MapReduce Details for Multimachine Clusters,a A regulates centrosome maturation and spindle assembly while Aurora B (and C) a chromosome passenger protein (CPP) regulates chromosome orientation on the spindle and cytokinesis. All 3 Auroras are overexpressed in a multitude of human cancers with an associated polyploid phenotype containing mult

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Advanced and Alternate MapReduce Techniques,than protein tyrosine kinases among the molecular entities that regulate cell proliferation. They have been extensively explored to determine their effectiveness as targets for discovery of novel anticancer agents. Polo-like kinases (Plks) comprise a family of conserved proteins that mediate numerou

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Advanced and Alternate MapReduce Techniques,f cancer cell lines, and inhibit tumor growth in vivo. The antiproliferative effects of HDACis are caused by drug induced G1 or G2 phase cell cycle arrests. They also promote aberrant mitosis, which in cycling cells can result in the rapid onset of apoptosis. Hyperacetylation of the constitutive cen

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The Basics of Multimachine Clusters,Mitotic kinesins are essential for the formation and function of the mitotic spindle during mitosis. The following pages describe some of the different roles of this class of enzymes on cell division and our current understanding of kinesin inhibitors in anticancer drug development.

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Kinesin Motor Inhibitors as Effective Anticancer Drugs,Mitotic kinesins are essential for the formation and function of the mitotic spindle during mitosis. The following pages describe some of the different roles of this class of enzymes on cell division and our current understanding of kinesin inhibitors in anticancer drug development.

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Checkpoint Responses in Cancer Therapy978-1-59745-274-8Series ISSN 2196-9906 Series E-ISSN 2196-9914

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https://doi.org/10.1007/978-1-4302-1834-0sm of the G2 checkpoint s cascade. In addition, screening procedures to identify candidate compounds, currently available compounds, and compounds in clinical trials with G2 checkpoint-abrogating potential are discussed.

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