| 書目名稱 | Central Neurotransmitter Turnover | | 編輯 | C. J. Pycock,P. V. Taberner | | 視頻video | http://file.papertrans.cn/224/223203/223203.mp4 | | 圖書封面 |  | | 描述 | The concept of chemical transmission in the central nervous system has taken some time to be generally accepted, but an increasing number of compounds are now being recognized as hav- ing a transmitter role in the brain. The acetylcholine system was the first to be discovered in the periphery and its charac- teristic features of storage of transmitter in vesicles in the nerve terminal, its electrically-evoked release and rapid extra- neuronal breakdown were considered to be necessary criteria for any neurotransmitter candidate. The subsequent elucidation of the noradrenergic system made it apparent that rapid enzymatic breakdown was not essential for a released transmitter, and the possibility of high-affinity re-uptake processes became establ- ished as an alternative means of terminating the synaptic actions of a transmitter. With the eventual acceptance of the amino acids as excitat- ory or inhibitory transmitters, the requirement for a transmit- ter to be present in a low concentration overall (although locally concentrated in specific terminals) also had to be discarded. This necessitated the additional concept of specif- ic metabolic pools with different functions being locate | | 出版日期 | Book 1981 | | 關(guān)鍵詞 | brain; catecholamines; nervous system; system; time | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4615-9778-0 | | isbn_softcover | 978-1-4615-9780-3 | | isbn_ebook | 978-1-4615-9778-0 | | copyright | C.J. Pycock and P.V. Taberner 1981 |
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