Titlebook: Centenarians; An Example of Positi Calogero Caruso Book 2019 Springer Nature Switzerland AG 2019 Aging.Longevity.Phenotype.Genetics.Epigene

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鑲嵌細(xì)工

978-3-030-20764-9Springer Nature Switzerland AG 2019

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Chance and Causality in Ageing and Longevity,xtreme limits of lifespan, avoiding or delaying major age-related diseases. The identification of the factors that predispose to long and healthy life is of tremendous interest for translational medicine. Here we briefly describe the results obtained so far and their meaning, focusing on the role of chance and causality.

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Genetic Signatures of Centenarians,tudy and back to the case–control study with SNPs array, imputation and whole genome sequencing. Results were analysed either independently or by combining different cohorts through meta-analysis. Furthermore, genetic signatures were identified that predict the phenotypic outcome of exceptional long-living individuals.

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https://doi.org/10.1007/978-3-642-45711-1 mechanisms involved in the pathogenesis of age-related diseases, as the pro- and anti-inflammatory pathways or the pro- and antioxidant systems and their contribution, are crucial to this aim. Moreover, the psychological and cognitive aspects must be taken into account. In this chapter, to understa