Titlebook: Cellular and Molecular Aspects of Ageing; Valquiria Bueno Book 2024 The Editor(s) (if applicable) and The Author(s), under exclusive licen

Pamphlet

Telomeres,and play an essential role in cellular longevity. These specialized structures undergo dynamic changes during cellular divisions and act as protective caps, preventing the loss of coding genetic material (due to peculiarities of the replication process) and the fusion of chromosomal ends. They also

輕觸

Epigenetic Changes in Aging: The Contribution of SIRT1 to Longevity,n aged organisms, a noticeable reduction in histones levels is accompanied by both local and global chromatin remodeling. This shift creates an imbalance between activating and repressive histone modifications, resulting in widespread transcriptional changes observed in various aging models. Sirtuin

meritorious

Proteostasis, Proteodynamics and Cellular Aging,out which the cell could not function properly. Organismal and cellular aging imposes stresses, constrains and dysfunctions on each and every stage of protein manufacturing, maturation and maintenance, as well as on the efficiency of removal of those proteins that were malformed (e.g. misfolded) fro

Magnificent

Mitochondria and Ageing,dered a regular process occuring in all living organisms, aging is associated with accumulative oxidative damage of cellular biomolecules and with increased susceptibility to age-related diseases. Mitochondria are central organelles in energy metabolism by housing several metabolic pathways and prod

Paleontology

insurrection

Cell-to-Cell Communication in Aging: Mechanisms, Impact and Therapeutic Prospects,rsal phenomenon that affects all living organisms and is characterized by a progressive reduction in both physical and mental capabilities, which is associated with an increased susceptibility to illness and mortality (Vi?a et al. in IUBMB Life. 59:249–254, 2007; Guo et al. in Signal Transduct Targe

Custodian

The Senescence-Associated Secretory Phenotype: Induction, Regulation, Function and Therapeutic Inteal of advanced age. Among the causes responsible for the induction of this status, the accumulation of senescent cells in the body play a relevant role. This chapter summarizes the features of senescent cells, how they are induced and maintained in the body and how they can contribute to the develop

Mobile

Cellular Senescence, which senescence is induced, mostly related to stresses inducing some type of DNA damage. Currently, cellular senescence is studied particularly in relation to aging and cancer. Data from animal experiments attribute a key role of cellular senescence in these biological processes, but in humans the

Gerontology

A Panorama of Iterated Revisionen numerous attempts to tackle this problem. In this chapter, we shall review some of the most influential approaches to the problem of iterated belief revision, and discuss their strengths and shortcomings.