Titlebook: Cell Therapy, Stem Cells and Brain Repair; Cyndy Davis Sanberg,Paul R. Sanberg Book 2007 Humana Press 2007 Activation.Nervous System.Parki

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,Cell-Based Therapy for Huntington’s Disease,he disease manifests in the third and fourth decades of life, and death is imminent usually within 20 yr. Its pathology is marked by cell loss in the striatal nuclei. Following the marked cell loss, enlargement of the ventricles is observed, as well as cortical degeneration. The aim of neural transp

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,Use of Bone Marrow Stem Cells as Therapy for Behavioral Deficits in Rodent Models of Huntington’s Den the donor and recipient are different individuals) transplants of adult, bone-marrow-derived stem cells to counteract the behavioral deficits produced by intrastriatal injections of quinolinic acid (QA) in rats, a rodent model for Huntington’s disease (.). These studies support previous findings

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Therapeutic Applications of Bone Marrow-Derived Stem Cells in Neurologic Injury and Disease,inductive cues. In the past hematopoietic stem cells were identified in bone marrow that have the capability to differentiate into cells that are part of the blood system. The cells therefore are restricted to the types of cells they can become. Recently, other types of stem cells such as mesenchyma

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Cell Therapy for Models of Pain and Traumatic Brain Injury,ury (TBI). As the goals of these two therapeutic targets are widely disparate, approaches have evolved along distinctive paths. Thus, although the provision of a local cellular source of pharmacologic analgesic molecules may be most appropriate in the management of chronic pain, central nervous syst

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The Use of Sertoli Cells in Neural Transplantation,uitable donor tissue necessitates the development of novel approaches to enable transplantation on a widespread basis. Transplantable cells obtained from xenogeneic sources have shown considerable promise in preclinical animal models, as well as in a limited number of human trials conducted to date.

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The Choroid Plexus,CP been implicated in other basic aspects of neural functioning, such as surveying the chemical and immunological status of the brain, detoxifying the brain, secreting a nutritive cocktail of polypeptides for neuronal function and survival, and participating in repair processes following trauma. The

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Progress and Challenges in Immunoisolation for CNS Cell Therapy,ature to the brain parenchyma. One method to overcome the BBB is with cellular implants that produce and deliver therapeutic molecules directly to the brain region of interest. Immunoisolation is based on the observation that xenogeneic cells can be protected from host rejection by encapsulating, or

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receptors