Titlebook: Cell Therapy for Perinatal Brain Injury; Haruo Shintaku,Akira Oka,Makoto Nabetani Book 2018 Springer Nature Singapore Pte Ltd. 2018 Stem c

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https://doi.org/10.1007/978-981-10-1412-3Stem cell therapy; CD34 cell; Neural stem cell; Mesenchymal stem cell; Ischemic disease; Clinical Trial

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Clinical Trial of Autologous Cord Blood Cell Therapy for Neonatal Hypoxic Ischemic Encephalopathy (gous non-cryopreserved volume- and red blood cell-reduced UCB is the most feasible method for cell therapy, especially when used at the acute phase of acute onset diseases. Fewer than ten clinical studies, including ours, using UCB for newborns with acute brain injury have been reported or listed on

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Hematopoietic Stem Cells for Perinatal Brain Injury,therapy with HSCs or the cell fraction containing HSCs has several advantages over other types of cell therapies. This approach does not require intracranial transplantation; intravenous transfusion seems sufficient for them to exert their beneficial effects. The cells are easily obtained, and neith

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Other Tissues-Derived Mesenchymal Stem Cells for Perinatal Brain Injury,UCBCs in emergency situations..MSCs can be used as alternative cells for the treatment of perinatal HIE because we can use allogeneic MSCs. In this chapter, I describe preclinical studies with various origins of MSCs as well as clinical studies.

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Clinical Procedure of Cell Therapy: Separation and Infusion, a day for 12?h to 3?days..This treatment was successful and safe in all three cases with no adverse effects. A randomized phase II study to provide further safety, feasibility, and efficacy information among a wider number of sites is warranted.

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Cell Therapy for Adult Infarction,garding cell therapy to enhance function recovery and introduces our clinical trial using autologous bone marrow mononuclear cells for adult patients with cerebral infarction. We also refer to a future strategy of cell therapy that aims to support ideal regenerative process after stroke in the adult

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Clinical Trials on Cell Therapy for Perinatal Brain Injury: Challenges and Opportunities,nt of new drugs. For instance, the Pharmaceuticals and Medical Devices Agency (PMDA) has established a special department for cellular and tissue-based products; furthermore, the PMDA has launched a conditional time-limited marketing authorization system. This system makes it possible to rapidly pro

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