Titlebook: Cell Signaling in Vascular Inflammation; Jahar Bhattacharya (Professor of Physiology and Ce Book 2005 Humana Press 2005 biology.calcium.ci

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Regulation of Cytokine Signaling,-13 are important cytokines for the regulation of these asthmatic immune responses. However, the cellular mechanisms that regulate IL-4 and IL-13 signaling remain unknown. Recently, a new family of proteins, termed . (SOCS), has been identified. We have previously shown that SOCS-1 is a potent inhib

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Reactive Oxygen Species and Cell Signaling in Lung Ischemia,sed shear stress by the endothelial cell, resulting in the activation of membrane-associated NADPH oxidase, generation of O(in2)-, and activation of a signaling cascade. The initial response of the endothelium leading to NADPH oxidase activation is depolarization of the endothelial cell membrane, po

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Pulmonary Vascular Barrier Regulation by Thrombin and Edg Receptors,tomyosin cytoskeleton with subsequent effects on cell—cell and cell—matrix interactions. Although the list of biochemical and biophysical agonists that alter EC barrier regulation is extensive, in this chapter we consider two in particular—the barrier-disruptive serine protease thrombin and barrier-

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Second-Messenger Signaling in Lung Capillaries,ing capillary proinflammatory processes is not clear. Mainly, it is not clear to what extent EC cytosolic Ca. increases activate other second messengers, which in turn might play a direct role in initiating proinflammatory responses. We determined this in intact lung capillaries using videomicroscop

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Signaling by Mitochondria,ion as important participants in a diverse collection of novel intracellular signaling pathways. Recent data demonstrate that mitochondria regulate molecular and cellular responses to low oxygen levels (hypoxia). Hypoxic conditions between 1 and 2% oxygen typically elicit an increase in transcriptio

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