Titlebook: Cell Motility Factors; I. D. Goldberg Book 1991 Birkh?user Verlag 1991 cancer.cell.migration.morphogenesis.skin

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Scatter factor stimulates migration of vascular endothelium and capillary-like tube formation,y of normal epithelium, carcinoma cells, and vascular endothelium. Human and mouse SFs have been purified and identified as 90 kD heterodimeric proteins consisting of heavy (58 kD) and light (31 kD) disulfide-bonded subunits. Partial amino acid sequence data from SF-derived tryptic peptides indicate

背景

The cellular response to factors which induce motility in mammalian cells,a factor which induces or enhances cell motility. Amongst biological agents which have this role are a number of growth and motility factors, and a variety of agents which stimulate leukocyte Chemotaxis, including formyl peptides (for a review see Rosen and Goldberg, 1989).

Carbon-Monoxide

The role of E-cadherin and scatter factor in tumor invasion and cell motility, 2 types of interferences leading to enhanced motility and invasiveness of epithelial cells: (i) disturbances of intercellular adhesion, and (ii) treatment with “scatter factor”, a secretory protein of mesenchymal cells. Invasive properties (invasion of collagen gels or embryonal heart tissue) are a

harmony

REP

加劇

Tumor cell autocrine motility factor receptor,(AMF) is a cytokine produced by various tumor cells which stimulates their . motility and . lung-colonizing ability. AMF stimulates cell motility via a receptor-mediated signalling pathway. Signal transduction following binding of AMF to its receptor, a cell surface glycoprotein of 78 kD (gp78), is

OASIS

APEX

Interleukin-6 stimulates motility of vascular endothelium,ine brain and bovine aortic endothelial cells, with maximal responses at 100-600 ng/ml. The migration response was inhibited by anti-IL-6 monoclonal antibody. IL-6 also . endothelial cell proliferation in a dose-dependent fashion. Combinations of IL-6 and tumor necrosis factor induced additive stimu

Tonometry

Computer automation in measurement and analysis of cell motility ,,nd morphology. This has stimulated interest in theoretical models of cell motility, and has prompted the need for increasingly sophisticated approaches to analyze and present cell motility data. In this article we review some of the microscope systems currently used to study cell motility, and give

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Adhesion systems in embryonic epithelial-to-mesenchyme transformations and in cancer invasion and mnetic events including gastrulation, neural crest migration, somitogenesis, the formation of kidney tubules, cardiac valves and the secondary palate (Thiery et al., 1985; Kolega, 1986; Duband et al., 1987). In the adult organism, epithelial cells are also capable of migrating in response to wounds i