Titlebook: Cell Encapsulation Technology and Therapeutics; Willem M. Kühtreiber,Robert P. Lanza,William L. Ch Book 1999 Springer Science+Business Med

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Anukrati Sharma,Venkata Rao Yedla, the substrate must be able to reach the bead/capsule interior to allow the biochemical reaction to occur, and the desired products must be able to diffuse out of the bead. Similarly with drug-delivery systems, the release of the bioactive agent from the polymer matrix or capsule must be controlled so as to give a constant steady release rate.

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Encapsulation and Immobilization Techniquesf cell immobilization. It is therefore not surprising that scientists and engineers seriously consider cell immobilization as a means of solving technological problems involving the handling and processing of cellular materials.

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Modulation of Membrane Permeability has been investigated is cell entrapment in a polymer gel or porous matrix. Although this method enhances greatly the available surface, and hence the cell density of the system, the problems of vulnerability to shear and immune assault are at best only partially mitigated. An additional complicati

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Biocompatibility Issues hemophilia B (Liu et al 1993), anemia (Koo and Chang 1993), dwarfism (Chang et al 1993), kidney (Cieslinski and Humes 1994) and liver (Uludag and Sefton 1993) failure, pituitary (Colton 1995) and central nervous system insufficiencies (Aebischer et al 1994), and diabetes mellitus (Lim and Sun 1980)

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