Titlebook: Case Studies inSystems Biology; Pavel Kraikivski Textbook 2021 Springer Nature Switzerland AG 2021 Dynamic modeling.Biological Networks.Bi

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,NF-κB Spiky Oscillations,inflammation, stress responses, and apoptosis. NF-κB is activated by many external stimuli, including bacteria, viruses, and various stresses and proteins, after which it initiates proper cell responses by regulating expression of various genes. The NF-κB signaling system is conserved to operate in

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Tick, Tock, Circadian Clocks,ke cycle, body temperature, blood pressure and hormone secretion [1]. The disruption of circadian rhythms increases the risk of getting various chronic diseases such as cancer, diabetes, mood disorders and sleep disorders [2]. The key oscillatory mechanism of the circadian clock is a transcriptional

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Modeling cAMP Oscillations in Budding Yeast,ce in the environment in order to modulate their metabolism, which is in turn vital to maintain an optimal growth rate. The cAMP/PKA signal transduction pathway performs this task: the pathway ‘senses’ environmental glucose and carries out a variety of biological roles, including activation of growt

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The , Operon,the digestion of available nutrients. The . system produces a switch-like dynamic behavior, where the switching between ‘on’ and ‘off’ states of . gene transcription depends on the specific thresholds of nutrient concentrations. As . operon regulation has been extensively studied and is one of the m