Titlebook: Cardiovascular Regenerative Medicine; Tissue Engineering a Vahid Serpooshan,Sean M. Wu Book 2019 Springer Nature Switzerland AG 2019 3D bio

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https://doi.org/10.1007/978-3-030-20047-33D bioprinting of cardiovascular tissues; Bioengineered cardiovascular tissues; Cardiac biomaterials; C

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978-3-030-20049-7Springer Nature Switzerland AG 2019

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Brand Fortner,Theodore E. Meyerers have used two-dimensional (2D) cell culture methods to elucidate the molecular mechanisms that drive diseases. However, this method of cell culture fails to recapitulate the complex, three-dimensional (3D) microenvironment that is present in vivo. Recently, tissue-engineered models have been gen

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Brand Fortner,Theodore E. Meyer introduce or correct disease-causing mutations, creates unprecedented opportunities for drug discovery. The new technologies have the potential to revolutionize the drug development pipeline, from delineating disease mechanisms and discovery of therapeutic targets to library screening and validatio

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https://doi.org/10.1007/978-94-015-9578-0nt therapies are restricted to pharmaceuticals, mechanical and electrical support devices, and synthetic materials. Decellularized extracellular matrices have strong potential to provide support to failing myocardium. Their native composition offers complex biochemical cues beyond what can be synthe

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https://doi.org/10.1007/978-94-015-9578-0rgoing current treatment modalities is bleak, due to the lack of regenerative capacity of native heart tissue. Tissue engineering and regenerative medicine have developed numerous strategies to repair or replace injured myocardium. One of the most promising strategies to date is the attempt to engin

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https://doi.org/10.1007/978-94-015-9578-0 method that is used for the generation of defined biological products from living cells, biomaterials, bioactive molecules, and extracellular matrices. As one of the mainstream technical routes in biofabrication, bioassembly has been widely used for generating 3D cardiac microtissues. In this chapt

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https://doi.org/10.1007/978-94-015-9578-0egies and secondary interventions have led to enhanced survival, many patients still succumb to heart failure. This necessitates the development of novel strategies to target the microvascular dysfunction and malperfusion which lead to progressive functional deterioration. Cardiovascular tissue engi

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