Titlebook: Cardiovascular Genetics and Genomics; Principles and Clini Dhavendra Kumar,Perry Elliott Book 2018 Springer International Publishing AG 201

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Inherited Cardiac Muscle Disorders: Arrhythmogenic Right Ventricular Cardiomyopathy,or cardiac arrest usually in adolescence or young adulthood. AC represents one of the major causes of sudden death in the young and athletes. The estimated prevalence of AC in the general population ranges from 1:2000 to 1:5000. AC affects more frequently males than females (up to 3:1), despite a si

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Inherited Cardiac Muscle Disorders: Left Ventricular Noncompaction,y, it is characterized by prominent ventricular trabeculae and deep intertrabecular recesses. It has traditionally been thought to be related to intrauterine arrest of myocardial development. While it is classified as a primary cardiomyopathy of genetic origin by the American Heart Association, the

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Inherited Arrhythmias: Brugada Syndrome and Early Repolarisation Syndrome,with malignant arrhythmias and sudden death in otherwise healthy young adults and even children. We discuss their history, clinical perspectives (including patient characteristics and epidemiology), the pathway to the diagnosis, pathophysiological mechanisms (including genetic associations) and revi

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Inherited Conduction Disease and Atrial Fibrillation,sinus node, atrial myocytes or conduction system can result in sinus bradycardia, atrial fibrillation (AF) or premature atrioventicular block..This chapter discusses the key molecular mechanisms determining the development of AF & conduction disorders. Both may exist as a monogenic disease, and rese

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Cardiovascular Manifestations in Duchenne/Becker Muscular Dystrophy and Other Primary Myopathies,asis, and as such this is the initial focus from a clinical perspective. Over the past decades, improvements in physical and respiratory therapy, coupled with advances in technology, have substantially improved quality of life for this patient group. Improvements in computer technology such as voice

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