Titlebook: Cardiomyocytes; Methods and Protocol Gary R. Skuse,Maureen C. Ferran Book 2015 Springer Science+Business Media New York 2015 Cardiac myocyt

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Deep Sequencing of Cardiac MicroRNA-mRNA Interactomes in Clinical and Experimental Cardiomyopathy,art to stress stimuli. As the sequence-specific recognition element of RNA-induced silencing complexes (RISCs), microRNAs bind mRNAs and prevent their translation via mechanisms that may include transcript degradation and/or prevention of ribosome binding. Short microRNA sequences and the ability of

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Next-Generation Sequencing Technology in the Genetics of Cardiovascular Disease,sible way for obtaining global genomic information. At present, three most NGS platforms are used in genetics for clonally amplified templates. These technologies share general processing steps but differing in specific technical details that determine their limits or advantages. NGS has been recent

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Computational Cardiac Electrophysiology: Implementing Mathematical Models of Cardiomyocytes to Simumake predictions requires solving the models computationally using numerical schemes. We discuss different solution methods and other computational considerations for simulating cardiac action potentials in single cells and multicellular preparations.

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Using the Mechanical Bidomain Model to Analyze the Biomechanical Behavior of Cardiomyocytes, extracellular matrix and the intracellular cytoskeleton of cardiomyocytes. The goal of this chapter is to introduce the mechanical bidomain model, to describe the mathematical methods required to solve the model equations, and to predict where the membrane forces acting on integrin proteins couplin

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Mouse Embryonic Stem Cell-Derived Cardiac Myocytes in a Cell Culture Dish,ee germ layers. In the absence of differentiation inhibitory factors, when cultured in suspension, ES cells spontaneously differentiate and form three-dimensional cell aggregates termed embryoid bodies (EBs). Although various methods exist for the generation of EBs, the hanging drop method offers re