Titlebook: Cardio-Renal Clinical Challenges; David Goldsmith,Adrian Covic,Jonas Spaak Book 2015 Springer International Publishing Switzerland 2015 An

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Anticoagulation in CKDrdial infarction, prosthetic valve replacement, and prevention and treatment of venous thromboembolism. The risk of stroke in patients with stage 3 CKD and end-stage renal disease (ESRD) is higher than that of the general population and, in combination with atrial fibrillation, necessitates oral ant

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MRA Inhibition in CKD: More Than Salt and Watermost important causes of CKD in developed countries are diabetic nephropathy and renovascular disease/hypertension. Despite a proven favorable effect of RAAS blockade on short-term parameters (blood pressure, proteinuria) as well as long term outcome (slower decline of GFR), progression of chronic k

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Uric Acid, Allopurinol: The Cardio-Renal Silver Bullet?scular events. Uric acid is the end product of purine metabolism that circulates in the plasma at concentrations varying from 2 to 10 mg/dl or higher. Purine nucleotides are derived from both exogenous (alimentary intake, especially animal proteins) and endogenous sources (. molecule synthesis and n

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FGF23 and Phosphate: Two Cardiovascular Toxins with Distinct Toxicity Profiles?n integral element of CRS-4 is dysregulated mineral metabolism including altered serum levels of calcium and inorganic phosphorus (Pi). Downstream biochemical consequences entail remarkable elevations in the principal hormones regulating serum calcium and Pi, including parathyroid hormone (PTH), and

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Effect of Vitamin D on Endothelial Function and Blood Pressurers and is increasingly associated with non-traditional risk factors [2]. Vitamin D deficiency is a non-traditional risk factor for cardiovascular events which becomes more relevant with declining renal function. At the same time, the deficiency of active vitamin D plays a major role in the mineral-b