Titlebook: Cardiac-Vascular Remodeling and Functional Interaction; Yukio Maruyama (Professor and Chairman),Masatsugu Book 1997 Springer Japan 1997 a

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Interaction Between Left-Ventricular Function and Loading Condition in Cardiovascular Diseasediac output is obtained, may not necessarily indicate optimal loading level in this type of cardiac dysfunction. This must be considered clinically when adopting afterload reducing therapy in regional ischemia. Moreover, when intraaortic balloon pumping (IABP) is used for patients with heart failure

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Adaptation of the Cardiac Cell to Loading: Function in Heart Failureinadequate gene expression. In consequence the amount of Ca. that is released during each heartbeat is less than normal, thus force is reduced. In normal heart muscle, the response of the contractile filaments to Ca. ions depends strongly on sarcomere length, thus explaining Starling’s law of the he

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Endocardial—Myocardial Interactionteracts with neurohumoral-mediated control. EE cells respond to physical and humoral stimuli with release of several substances that have important inotropic actions on the myocardium. Specific electrophysiological properties determine the intracellular Ca. increase in response to external stimuli a

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Optimal Afterload that Maximizes External Work and Optimal Heart that Minimizes O2 Consumption (0.69 ± 0.26 [SDI]. .. was 0.93 ± 0.08, suggesting that the external work of the left ventricle was nearly maximum at this condition. Similarly, .. was 0.98 ± 0.01, indicating that myocardial oxygen consumption was almost minimum. When dogs ran on a treadmill, their heart rate and cardiac output do

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