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Titlebook: Cardiac Rate and Rhythm; Physiological, Morph Lennart N. Bouman,Habo J. Jongsma Book 1982 Martinus Nijhoff Publishers, The Hague 1982 drugs

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發(fā)表于 2025-3-21 17:29:52 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Cardiac Rate and Rhythm
副標(biāo)題Physiological, Morph
編輯Lennart N. Bouman,Habo J. Jongsma
視頻videohttp://file.papertrans.cn/222/221812/221812.mp4
叢書名稱Developments in Cardiovascular Medicine
圖書封面Titlebook: Cardiac Rate and Rhythm; Physiological, Morph Lennart N. Bouman,Habo J. Jongsma Book 1982 Martinus Nijhoff Publishers, The Hague 1982 drugs
描述In the denervated state the mammalian heart, both in vivo and in vitro, is excited at very regular intervals, the coefficient of variance of the interbeat intervals not exceeding 2%. The pacemaker that is the source of this regular ex- citation is localised normally within the sinus node (" sino-atrial node " node of Keith and Flack), a most intriguing small piece of tissue in the caval corner of the right atrium. A small portion of this node containing a group of probably only a few thousands of cells fires spontaneously, that means without any exter- nal influence to trigger their activity. The so called pacemaker cells do this by letting their membrane potential fall to the level where an action potential will start which subsequently activates surrounding cells to fire an action po- tential. The first question which is tackled in this book is which processes underly this spontaneous diastolic depolarization. This is discussed in section I, concerning the fundamental properties of pacemaker cells with special refer- ence to ionic membrane currents. Although views still quite differ about the exact nature of the membrane processes that cause the automatic pacemaker dis- charge th
出版日期Book 1982
關(guān)鍵詞drugs; heart; heart rate; membrane; pacemaker
版次1
doihttps://doi.org/10.1007/978-94-009-7535-4
isbn_softcover978-94-009-7537-8
isbn_ebook978-94-009-7535-4Series ISSN 0166-9842
issn_series 0166-9842
copyrightMartinus Nijhoff Publishers, The Hague 1982
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The Relative Contributions of Various Time-Dependent Membrane Currents to Pacemaker Activity in the n reality a developing inward current which cannot be carried by potassium ions alone (see DiFrancesco, this volume). It probiably has the same ionic composition as i. (i.) in the SA node and is carried by both sodium and potassium ions (DiFrancesco, 1980; Brown et al., 1980). This being the case, b
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The Current IK2 in Purkinje Fibres Reinterpreted and Identified with the Current IF in the SA Nodef any K-dependent current is far more drastic than any distortion induced by non-uniformities. Indeed, evidence given in this paper shows how the presence of strong K-depletion during hyperpolarizations can alter the analysis of the pacemaker current “i.” so substantially as to make an inward curren
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Cellular Communication: Introductory Remarksnimale Zellketten (...): die einzelnen Zellen vermoegen sich zwar waehrend des Lebens den Erregungsvorgang durch Contakt mitzutheilen, sterben aber jede fuer sich ab”. In a publication dated 1876 Engelman attempted to extend the general validity of his idea to single nerve fibres. His observations,
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Formation and Growth of Myocardial Gap Junctions: In Vivo and In Vitro Studiese communicating unit (i.e., “connexon”) is a hexameric polymer which spans the membrane and would possess a central channel. It has been speculated that rotational displacement of the subunits to glide against each other, represents the mechanism whereby the channel is opened and closed.
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Normal and Malignant Hematopoiesislic depolarization. This is discussed in section I, concerning the fundamental properties of pacemaker cells with special reference to ionic membrane currents. Although views still quite differ about the exact nature of the membrane processes that cause the automatic pacemaker discharge there is agr
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