Titlebook: Cardiac Mechanotransduction; Matti Weckstr?m,Pasi Tavi Book 2007 Springer-Verlag New York 2007 Cardiac.Mechanotransduction.Weckstr?m.bioch

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Book 2007e return of blood into the heart and the blood pressure with cardiac con- traction force. The "law" does it in a way that enables the cardiovascular system to react to perturbations without major malfunctions. This book is a compilation of reviews of prominent scientists on this subject. The differ-

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Origin of Mechanotransduction,aling cascades and ultimately may contribute to remodeling of the heart in response to hemodynamic stress. This chapter reviews the transmission of mechanical forces, the biophysical characteristics of cardiac SAC, and how SAC activity may be coupled to signaling cascades and thereby initiates the complex response of the heart to stretch.

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The Mechanosensory Heart,ly serve the same functions. This ability, interesting by itself, has also a medical significance because it is associated with disturbances that may develop if a sustained loading of the myocytes will change their function. This may lead to adaptational growth of the cardiac muscle, but also to ser

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The Role of the Sarcomere and Cytoskeleton in Cardiac Mechanotransduction,filament. Actin filaments are directly connected to the Z line of the sarcomere, whereas myosin filaments are secured via the giant elastic protein titin. When cardiac muscle is stretched there is an immediate increase in contractility. This is an acute and fundamental cardiac adaptive response to a

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Second Messenger Systems Involved in Heart Mechanotransduction,yocytes. Therefore, it is important to understand how mechanical loading is sensed by cardiomyocytes and converted into intracellular biomechanical signals leading to cardiac hypertrophy. When mechanical stress is received it is converted also into biochemical signals inside the cells. The signal tr

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