Titlebook: Cardiac Mechanobiology in Physiology and Disease; Markus Hecker,Dirk J. Duncker Book 2023 The Editor(s) (if applicable) and The Author(s),

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Mechanobiology of Cardiac Growth in Health and Disease,rs in developmental biology, tissue homeostasis, and pathology programming. In fact, the evidence that cells are able to translate mechanical cues in the form of strain/stretch- or positional-/geometric-dependent information, adds a new complexity to the coordination of the multicellular regulation.

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The Role of Mechanosensitive Signaling Cascades in Repair and Fibrotic Remodeling of the Infarcted uires stimulation of an inflammatory reaction and subsequent activation of matrix-secreting myofibroblasts. Perturbed myofibroblast function results in defective healing and may cause rupture and adverse dilative remodeling, whereas prolonged, excessive, or unrestrained fibrogenic actions following

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Mechanobiology of Cardiac Fibroblasts in Cardiac Remodeling,lular matrix (cECM) are the primary responsibility of cardiac fibroblasts (CFs). Long considered to be passive contributors to cardiac mechanics and function, CFs have undergone a major reevaluation in the past two decades and are now considered to be critical drivers of cardiac homeostasis. Primary

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Biophysical Stretch Induced Differentiation and Maturation of Induced Pluripotent Stem Cell-Derivedrdiovascular disease, accelerating drug discovery, exploring the earliest stages of human development, and boosting potential regenerative therapeutics. While it is now feasible to produce human patient- and disease-specific iPSC-CMs at a scalable level with high purity, their fetal-like phenotypes

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Mechanical Considerations of Myocardial Tissue and Cardiac Regeneration,use in clinical practice, none has demonstrated great success in regenerating the cardiac tissue. Therefore, there are still significant challenges in repairing or regenerating cardiac tissue, which serves a predominantly biomechanical function. Furthermore, it is now evident that the mechanobiologi

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Mechanobiology of Exercise-Induced Cardiac Remodeling in Health and Disease,ardiac remodeling, resulting from repetitive exposure to intense exercise, describes the process by which adaptations in myocardial structure and function occur. The athletic heart is typically characterized by either eccentric or concentric hypertrophy, depending on the type of exercise undertaken.