Titlebook: Cardiac Arrhythmias: New Therapeutic Drugs and Devices; Proceedings of the S Joel Morganroth,E. Neil Moore Conference proceedings 1985 Mart

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Nonlinear Diffusion-Reaction Phenomena,s ratio is invariably tilted in the risk direction, however slightly, when a healthy subject takes part in a Phase I study of any chemical compound. Tolerance, if not related to therapeutic effect, has littile practical import. Why expose healthy volunteen to a test compound until adverse effect occ