Titlebook: Candida albicans: Cellular and Molecular Biology; Rajendra Prasad Book 2017Latest edition Springer International Publishing AG 2017 Fungal

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AMPlified Defense: Antimicrobial Peptides During , Infection,perficial, as well as life-threatening infections. A complex balance of host immune defense mechanisms and fungal responses determine the level of fungal colonization or infection. Humans express a large number of various antimicrobial peptides (AMPs) with antifungal action that are key effectors of

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galley

Chromosome Components Important for Genome Stability in , and Related Species, to this trend. It is not only a fitter pathogen but also a successful gut commensal in humans. The extraordinary genome plasticity of . makes its survival possible in such widely diverse host niches. This chapter focuses on various chromosomal elements that are involved in maintaining the genome dy

ACRID

,Infection-Associated Gene Expression—The Pathogen Perspective,ave several technologies that allow precise measurement of RNA levels during infection. Together these capabilities allow us to infer many major signals that drive pathogen gene expression during infection. These signals and responses in turn yield insight into therapeutic targets for which inhibiti

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dermatomyositis

Mechanisms of Drug Resistance in ,,al pathogen. The decreased activity of these drugs in . as a result of resistance has been observed in different scales for every currently used drug classes. The occurrence of resistance, generally acquired by genetic alterations, can be considered as a natural defense mechanism of . against drugs

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Unlocking the Therapeutic Potential of the Fungal Cell Wall: Clinical Implications and Drug Resistal components—glucan, chitin and mannoproteins—are assembled and stabilised in the cell wall space by the action of cell wall-associated enzymes and structural wall proteins. Cell surface proteins are also important in . virulence. The components of the cell wall are unique to fungi, thus making the

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Iron Acquisition in the Pathobiology of ,,as well as for ..?.. However, iron sequestration in host proteins confers ‘nutritional immunity’. In this chapter, we have reviewed our current understanding of the different iron uptake systems, the associated genes, and their transcriptional regulation in ..?.. Besides, iron acquisition is essenti

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,Structure–Function Analyses of Multidrug Transporters,for the uptake of nutrients and the efflux of signalling molecules and toxic compounds. In the human opportunistic pathogen . efflux proteins can translocate antifungal drugs, such as fluconazole, and confer drug resistance. There are two main families of membrane proteins involved in drug transport