Titlebook: Cancer Therapy; Differentiation, Imm Natale D’Alessandro,Enrico Mihich,Thomas R. Tritto Conference proceedings 1993 Springer-Verlag Berlin

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Potential Role of Tumor Cell Antigen Modulation in Cancer Immunotherapy,cinoma cell population. Several clinical trials utilizing MAbs conjugated with radionuclides have shown preferential localization to human carcinomas (Colcher ., 1987a, b; Colcher ., 1990; Schlom ., 1989, 1991). Among the various MAbs generated, MAb B72.3 has been extensively used in clinical trials

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Natale D’Alessandro,Enrico Mihich,Thomas R. Tritto

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1010-8793 , which may support or evensubstitute chemotherapy: differentiation, immunomodulation,and inhibition of angiogenesis.Differentiation shouldnormalize neoplastic cells and makethem compatible with the host. Itsfeasibility withretinoids, interferons, chemotherapeutic and other agentsisdiscussed. Modula

ALTER

https://doi.org/10.1007/978-1-4020-6176-9osyl cytosine, daunomycin and actinomycin D have been shown capable of inducing tumor cell maturation [1,2,4,6,8,11,13,15,16,18–30], and we have examined the mechanism by which they initiate the maturation process.

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https://doi.org/10.1007/978-1-4020-6176-9ng that the increased number of malignant cells in the bone marrow and in the blood is due to an accumulation more than to a proliferative effect. The accumulation is the consequence of a long survival of malignant cells probably due to an impairment of the cell death program related to the immaturity of the cells.

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ATRA Therapy in Acute Promyelocytic Leukemia a Model for Differentiation Therapy,ng that the increased number of malignant cells in the bone marrow and in the blood is due to an accumulation more than to a proliferative effect. The accumulation is the consequence of a long survival of malignant cells probably due to an impairment of the cell death program related to the immaturity of the cells.