Titlebook: Cancer Therapeutic Targets; John L. Marshall Living reference work 20200th edition Anti-angiogenic Targets.HER2/EGFR Targets.Nuclear Rece

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Chiara Francalanci,Ajaz Hussainspecific groove of anti-apoptotic Bcl-2 family survival factors in a similar manner to native proteins within the cell that regulate these factors. This primes the cell for apoptosis. Several small molecule BH3 mimetics are currently undergoing evaluation in clinical trials.

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Brian Donnellan,Markus Helfert,Robert Winterlation of apoptosis is a fundamental component of some tumors. At least 15 caspases have been identified. Mutations and polymorphisms of caspase genes have been described in several solid tumors, and these mutations may prevent damaged cells from being destroyed and may facilitate development of met

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Miloslava Plachkinova,Ken Peffers,Greg Moody tumors of low immunogenicity. CCL21 mediates the recruitment and co-localization of naive lymphocytes and antigen-stimulated DC into T-cell zones of secondary lymphoid organs, facilitating T-cell activation. In this chapter, we discuss CCL21 as a novel agent to boost immune responses against cancer