Titlebook: Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology; Sadegh Babashah Book 2015 Springer International P

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https://doi.org/10.1057/9781137394750s. Auspicious outcomes have also been reported either by targeting pathways selectively operating in CSCs (e.g. Hedgehog, Wnt, Notch and FAK) or by using specific CSC cytotoxic agents. Other compounds are able to attenuate the unique stemness properties of CSCs by forcing cell differentiation, and t

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Cytokine Networks and Cancer Stem Cellss that utilize a range of intracellular signaling pathways to communicate this to the nucleus, rapidly impacting on the transcription of target genes in order to elicit the desired response, such as proliferation, differentiation, activation, and survival. Dysregulation of these important signaling

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Non-coding RNAs in Cancer and Cancer Stem Cellslls, including those involved in self-renewal, differentiation, and the regulation of specific gene expression. Although the properties of CSCs, such as tumorigenicity and resistance to conventional therapeutics, have been the focus of intensive research in the field of cancer, the molecular mechani

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Self-Renewal Pathways in Mammary Stem Cells and Carcinogenesism cells (BCSC) are resistant to traditional treatments and able to initiate tumorigenesis, suggesting that they may contribute to therapy resistance and relapse. The expression of specific markers in BCSCs and development of mouse model has facilitated the study and several intrinsic and extrinsic p