Titlebook: Cancer Metastasis — Related Genes; Danny R. Welch Book 2002 Springer Science+Business Media Dordrecht 2002 cancer.cancer research.carcinom

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The Emerging Role for the mRNA Cap-Binding Protein, EIF-4E, in Metastatic Progression,), apoptosis suppressors (bcl-2), angiogenesis factors (VEGF), and proto-oncoproteins (c-myc, cyclin D1). Expression of each of these potent proteins is profoundly influenced by the activity of the mRNA cap-binding protein, eIF-4E. Indeed, eIF-4E overexpression has been shown to selectively influenc

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Book 2002tic cells dissociate from the primary tumor, enter a circulatory compartment (typically lymphatics or blood vasculature), survive transport, arrest, exit the circulation and finally proliferate at a discontinuous site in response to local growth factors. Unless cells accomplish every step of the met

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Gene Regulation in Melanoma Metastasis,fected cells displayed down regulation of MCAM/MUC18 and MMP-2 and re-expression of the c-KIT receptor. Because AP-2 also regulates other genes that are involved in the progression of human melanoma, such as E-cadherin, p21/WAF-1, HER-2, Bc1-2, IGF-R1, FAS/APO-1 and the thrombin receptor (PAR-1), we

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The Emerging Role for the mRNA Cap-Binding Protein, EIF-4E, in Metastatic Progression,erefore represent a novel, compelling target for therapeutic intervention. Indeed, blocking eIF-4E activity dramatically suppresses malignancy by specifically suppressing the expression of key malignancy-related genes like cyclin D1, bFGF, VEGF and ODC (47 and references therein). Blocking eIF-4E ac

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https://doi.org/10.1007/978-3-031-26490-0d metastatic tumors. Tumors that over-expressed . RNA showed significantly higher rates of invasion and lymph node metastasis and tended to have higher rates of vascular involvement..Experimental inhibition of MTA1 protein expression using antisense phosphorothioate oligonucleotides resulted in grow