Titlebook: Cancer Metabolism; Methods and Protocol Majda Haznadar Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 Human B

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Martin Riopel,Zacharoula Smyrnaiouue used for many years in the study of cell metabolism. Conventional experiments using LCMS and labeled nutrients tend to track the incorporation of .C from exogenous nutrients (such as amino acids) into other, relatively proximal, cellular metabolites. Several labs have extended this technique to t

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Martin Riopel,Zacharoula Smyrnaiouo healthy noncancerous cell types, providing a unique metabolic marker. This feature has also been exploited for therapeutic use by utilizing drugs that specifically accumulate in the mitochondria of cancer cells with high Δψ.. As such, the assessment of Δψ. can provide very useful information as to

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Diane Pruneau,Jackie Kerry,Joanne Langis end, tumor-associated macrophages (TAMs) have been studied extensively and were found to be typically correlated with poor prognosis in various cancers. TAMs are key elements of cancer-associated inflammation promoting cancer progression by increasing angiogenesis, inducing immunosuppression of the

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I. Kósa Somogyi,M. Koós,V. A. Vassilyev, facilitates the accessibility of DNA for gene transcription. The central metabolite, acetyl-CoA, is a substrate for acetyltransferases, which catalyze protein acetylation. Acetyl-CoA is an essential intermediate in diverse metabolic pathways, and cellular acetyl-CoA levels fluctuate according to e

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