Titlebook: Cancer Management in Man; Biological Response Paul V. Woolley Book 1989 Kluwer Academic Publishers 1989 Tumor.antibiotics.biology.bone mar

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BLAND

Transcatheter Management of Neoplams,in the human body. The interventional radiologist has integrated these techniques with others derived from established surgical procedures for a more aggressive approach to the management of the cancer patient. Our ability to gain access to neoplasms by either direct punctures or through vascular ca

盡忠

Antifolates,n is exogenous. All biologically relevant coenzymatic forms of folic acid possess a tetrahydropteridine ring system (11). Folic acid is converted to 5,6,7,8-tetrahydrofolic acid by a stepwise reduction mediated by the key enzyme dihydrofolate reductase (EC 1.5.1.3). The stereochemistry of the enzyma

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起草

Alkylating Agents, (RX) which react with nucleophilic (electron-donating) centres (Y) to form covalently bound products (RY) containing the alkyl group (R). The binding of alkylating agents to cellular macromolecules is thought to be largely responsible for the . cytotoxic action of these compounds. Unfortunately the

起草

Cupping

Nitrosoureas,l tumors than any other class of agents and are one of the few groups of compounds to cross the so-called blood-brain barrier at therapeutically effective concentrations. Clinically the nitrosoureas are used against a variety of human solid tumors. There continues to be of interest in the developmen

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locus-ceruleus

Actinomycin,ore, which imparts a bright red color to the compound, and two cyclic peptide lactone side chains of variable composition. The most potent and widely used of these is Actinomycin D which is often called dactinomycin (Figure 1). In addition to the naturally occurring actinomycins a large number of sy