Titlebook: Cancer Immunotherapy Meets Oncology; In Honor of Christop Cedrik Michael Britten,Sebastian Kreiter,Hans-Geor Book 2014 Springer Internation

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https://doi.org/10.1057/9780230597952 agents and by the plasticity of the immune system to select such receptors and to make many copies on demand. Constructing “ein Gedankengeb?ude” to explain the observations made by Emil von Behring and Shibasaburo Kitasato (1890), he not only created the term “Antik?rper” (antibody) to describe suc

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Dirk Buyens,Tine Vandenbossche,Ans De Vosy products such as monoclonal antibodies have successfully been developed during the last years and contributed to major advances in cancer therapy. Development of cancer vaccines seemed to be more challenging. Nevertheless, some promising candidates are currently in late-stage clinical development,

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Dirk Buyens,Tine Vandenbossche,Ans De Vosng T cells and studies consequently showing that therapeutic interventions which are based on transfer, activation and expansion, or de-blocking of tumor-specific T cells, which have met with clinical success. To optimally profit from the flow of newly developed immune-based therapeutics aiming to r

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Dirk Buyens,Tine Vandenbossche,Ans De Vosmmunotherapy extends beyond a century with its most noteworthy successes having occurred just in the last 3 years. New drugs in this space – both approved and under investigation – demonstrate increased levels of benefit for patients, and their development is based on progress in basic science and i

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New Challenges for Macroeconomic Policiesnherent adjuvant activity. As compared to DNA-based approaches, in vitro-transcribed messenger RNA (mRNA) is a safer drug format due to the adjustable, transient expression and lack of genomic integration. In contrast to viral vector vaccines, mRNA vaccination is not limited by the emergence of immu