Titlebook: Cancer Imaging with Radiolabeled Antibodies; David M. Goldenberg Book 1990 Kluwer Academic Publishers 1990 Antigen.Staging.Tumor.carcinoma

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Antibody targeting: Theoretical considerationsreby developed into mathematical models to assess the potential and limitations of the technique. This allows a clear understanding of the physical and biologic problems that need to be solved. At present fairly superficial lesions, between 1/2 and 1 cm in diameter, are likely to be detected with an

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Experimental model systems for antibody targeting and radioimmunodetectionf animal models in radiotracer studies, including radiolabled antibodies, has been reviewed [1]. The first animal studies in the field of radioimmunodetection (RAID) were performed in the late 1940s and early 1950s. In a study to determine if anti-organ antibodies could localize specifically to the

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Preclinical models and methods for the study of radiolabeled monoclonal antibodies in cancer diagnos forming cells, numerous monoclonal antibodies have been generated against human and animal cancer cell surface markers for their potential use in cancer diagnosis and therapy [2–4]. To better understand the clinical utility of these antibodies, various animal models have been utilized.

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Physiology of monoclonal antibody accretion by tumors exquisite specificity and great utility for the diagnosis and treatment of cancer and other diseases [1]. Over the past 11 years numerous monoclonal antibodies have been generated using human tumor cell lines [2,3] and tumor homogenates [3,4] as the source of immunogen. Many of these antibodies whe

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