Titlebook: Cancer Drug Resistance; Overviews and Method Jose Rueff,António Sebasti?o Rodrigues Book 2016 Springer Science+Business Media New York 2016

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Classical and Targeted Anticancer Drugs: An Appraisal of Mechanisms of Multidrug Resistance, for more than 30 years. The identification of P-glycoprotein (P-gp), a drug efflux transporter protein with affinity for multiple therapeutic drugs, provided an important potential mechanism and further work, which identified other members of ATP-binding cassette (ABC) family that act as drug trans

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In Vitro Methods for Studying the Mechanisms of Resistance to DNA-Damaging Therapeutic Drugs, mechanism that enables cancer cells to survive through eliminating the damaged DNA lesions and thereby developing resistance to DNA-damaging agents. This chapter describes the four experimental approaches for studying DDR and genotoxic drug resistance, including the use of γ-H2AX and comet assays t