Titlebook: Cancer Drug Resistance; Beverly A. Teicher Book 2006 Humana Press 2006 angiogenesis.cancer.cytotoxicity.drug.drug resistance.hormones.imag

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2196-9906 cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, an

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Californium-252 as a Neutron Source for BNCTs. This chapter focuses on recent experimental evidence concerning two of the features most commonly encountered in multidrug resistant cancer cells: (over)expression of multidrug transporters and disabling of apoptotic pathways.

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Molecular Determinants of Intrinsic Multidrug Resistance in Cancer Cells and Tumorss. This chapter focuses on recent experimental evidence concerning two of the features most commonly encountered in multidrug resistant cancer cells: (over)expression of multidrug transporters and disabling of apoptotic pathways.

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Influence of Tumor pH on Therapeutic Responselysis by the tumor cells. In general, the extracellular pH (pHe) in human tumors is below 7.0, whereas the intracellular pH (pHi) is maintained at neutral range, i.e.,>7.0, by powerful pHi control mechanisms. The low pHe and the significant gradients between pHe and pHi affect markedly the response

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