Titlebook: Cancer Cytogenetics; Methods and Protocol John Swansbury Book 20031st edition Humana Press 2003

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1064-3745 tutorials on the fundamentals of human karyotypes and chromosome analysis, but also detailed discussions on how laboratories may optimally upgrade their repertoire of capabilities to include such newer complementary techniques as CGH, FISH, and M-FISH.978-1-59259-363-7Series ISSN 1064-3745 Series E-ISSN 1940-6029

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Conventional Cytogenetic Techniques in the Diagnosis of Childhood Acute Lymphoblastic Leukemia,especially useful in diagnosing the leukemic subtype and predicting treatment outcome. Molecular analysis of genes adjacent to the breakpoints of specific translocations and the study of the functions of their gene products have helped to clarify the complex interactions that promote leuke-mogenesis and perpetuate the leukemic phenotype (.).

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Other Lymphoid Malignancies, the methods described here are Phytohemagglutinin (PHA) for T-cells (..), and 12-.-tetradecanoyl-phorbol-13-acetate (TPA) for B cells. Other B-cell mitogens are described in .. Be aware that no mitogen is absolutely specific to T cells or B cells (..).

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Tracing with Radiolabeled Neurotrophinsabnormal cell, which usually tends to expand and eventually suppress or replace the growth and development of normal blood cells. This group of disorders includes the following: .The major clinical and cytogenetic features of the myeloid malignancies are summarized in the following subheadings.

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Carrie G. Causing,Freda D. Miller-B, common (cALL), and mature B stages. The last stage constitutes FAB type L3, which has a very close affinity with Burkitt lymphoma; these two disorders share identical cytogenetic abnormalities and both are now formally termed Burkitt cell lymphoma (BL).

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