Titlebook: Cancer Chemotherapy by Infusion; Jacob J. Lokich Book 1987 Precept Press, Inc. 1987 Staging.brain tumors.carcinoma.cell.classification.cli

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Periwinkle Alkaloids I: Vinblastine and Vindesinehe mechanism of action of these drugs has been extensively reviewed elsewhere.. These drugs have a very high affinity for tubulin and inhibit its polymerization. This leads to mitotic arrest and subsequent cell death. The vinca alkaloids are most active against premitotic cells and thus are cell cycle phase-specific agents.

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特征

Bleomycinors, most notably testicular cancer, lymphomas, and squamous cell carcinoma of the head and neck. Its lack of myelotoxicity led to its early use in combination chemotherapy programs. The primary dose-limiting toxicity of bleomycin is pulmonary fibrosis.

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GROSS

rapy can no longer be viewed as simply a palliative contribution. Chemotherapy has assumed an important role as an adjuvant to other modalities, including both surgery and radiation therapy. For some tumors, the primary application of chemotherapy in a combined modality approach to curative therapy

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Thomas L. Schwarz,Andrea J. Yools,. clinical use of the drug has been restricted to treatment of rapidly dividing tumors such as the leukemias. Recent interest has focused on ara-C as a potential differentiating agent when given in low doses over a prolonged infusion.