Titlebook: Cancer Chemoprevention; Volume 2: Strategies Gary J. Kelloff,Ernest T. Hawk,Caroline C. Sigman Book 2005 Humana Press 2005 carcinoma.endosc

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Preclinical Animal Models for the Development of Cancer Chemoprevention Drugss with the aim of preventing human cancer. If little is known about a potential agent, the first step is a sequential series of short-term in vitro prescreens of mechanistic, biochemical assays. These assays provide quantitative data to help establish an early indication of chemopreventive efficacy

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Modeling Human Colorectal Cancer in Mice for Chemoprevention Studieshas focused on human cancer cell lines and xenografts of human cancer cells in immunologically compromised mice. Though these experimental approaches have provided much information on cancer cells, they have precluded any insight into the intricate cross-talk between transformed cells and the host i

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Pathology of Incipient Neoplasiamor development. However, many of the morphologic and molecular abnormalities found in malignant tumors also exist in precursor or incipient lesions. New laboratory techniques, such as microdissection and polymerase chain reaction (PCR), have stimulated interest in early cancer development and event

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Enabling Discovery Through Online Cancer Genome Databases and Analytic Toolsic events associated with cancer are quite diverse, with much genetic heterogeneity within and among tumors, careful analysis of the complex data has revealed a limited number of common categories of acquired capabilities of cancers (.). As described by Hanahan and Weinberg, these capabilities inclu

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Functional Genomics for Identifying Surrogate Endpoint Biomarkers in Breast Cancer Chemoprevention a few immunohistochemical markers in tumors have guided treatment of most cancers. By studying gene expression patterns for a large number of genes, morphologically similar tumors can be further subdivided into distinct categories of clinical relevance. Recent studies have applied DNA microarrays t

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Clinical Applications of Proteomicsns and their possible post-translational modifications. However, the effort made to elucidate this index is not likely to be rewarded by any real clinical impact, as the function of proteins is closely tied to their cellular, tissue, and physiological context. The ultimate goal of clinical proteomic