Titlebook: Cancer Cell Signaling; Methods and Protocol Martha Robles-Flores Book 2014Latest edition Springer Science+Business Media New York 2014 Canc

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Methods for the Study of Long Noncoding RNA in Cancer Cell Signalinghis finding prompted intensive investigations on the biological functions of noncoding RNAs and led to very exciting discoveries of microRNAs as important players in disease pathogenesis and therapeutic applications. Research on long noncoding RNAs (lncRNAs) is in its infancy, yet a broad spectrum o

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An In Vivo Model to Study the Effects of Tumoral Soluble Factors on the Vascular Permeability in Mic expression of adhesion molecules on the apical membrane, and an increased permeability, which may contribute to the extravasation process of circulating cells. We have adapted the Miles assay into a protocol that uses IgE/antigen complex and VEGF-1 as controls. The Miles assay comprises the intrade

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Use of the Tumor Repressor DEDD as a Prognostic Marker of Cancer Metastasisting cell mitosis. Our recent work demonstrates that DEDD is a novel tumor repressor, which impedes metastasis by reversing the epithelial–mesenchymal transition (EMT) process in breast and colon cancers. DEDD expression therefore may represent a prognostic marker and potential therapeutic target fo

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Zebrafish-Based Systems Pharmacology of Cancer Metastasiserged as a powerful tool for identifying disease mechanisms, drug target molecules and small bioactive compounds over the last decade. Importantly, the immaturity of the zebrafish larvae immune system compared with that of mammals facilitates the implantation of human tumors representing aggressive