Titlebook: Camptothecins in Cancer Therapy; Val R. Adams,Thomas G. Burke Book 2005 Humana Press 2005 DNA.biochemistry.brain.brain tumors.cancer.cance

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Camptothecins in the Treatment of Lung Cancerrising, leveled off to the current incidence rate of 52.4 per 100,000. Overall, the 1-year survival rates for lung cancer have increased from 34% in 1975 to 42% in 1998, mainly because of improvements in surgical techniques. However, the 5-year relative survival rate for all stages is only 15% (.).

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2196-9906 logy, and the chemistry of the camptothecins, including the mechanism of topoisomerase and how camptothecins poison this enzyme, the use of animal models in defining the anticancer potential of camptothecins, and the question of camptothecin resistance.978-1-62703-816-4978-1-59259-866-3Series ISSN 2196-9906 Series E-ISSN 2196-9914

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2196-9906 for improving their clinical performance. The authors discuss new camptothecin analog development, drug delivery issues for optimizing their anticancer activity, and their potential use in a variety of different cancers. Additional chapters describe what is known about the biochemistry, the pharmaco

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Golam M. Khandaker,Urs Meyer,Peter B. Jonestanding of the drug’s mechanism of action (.). The finding in 1985 that CPT specifically poisons Top1 has generated great interest to find water-soluble, more efficacious, and less toxic analogs of CPT.

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Cytotoxic Mechanisms of Topoisomerase 1 Inhibitorstanding of the drug’s mechanism of action (.). The finding in 1985 that CPT specifically poisons Top1 has generated great interest to find water-soluble, more efficacious, and less toxic analogs of CPT.

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