Titlebook: Calcium Signalling and Disease; Molecular pathology Ernesto Carafoli,Marisa Brini Book 2007 Springer Science+Business Media B.V. 2007 ATP.

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The plasma membrane calcium ATPase and disease,ns of the . and . genes in mouse are embryonic lethal and cause a sperm motility defect, respectively. These phenotypes point to complex human diseases like hearing loss, cardiac function and infertility. Changes in PMCA expression are associated with other diseases including cataract formation, car

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Calcium and Cell Death: The Mitochondrial Connection,ant for metabolic regulation, can become a death factor by inducing opening of the permeability transition pore (PTP), a high conductance inner membrane channel. Persistent PTP opening is followed by depolarization with Ca. release, cessation of oxidative phosphorylation, matrix swelling with inner

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0306-0225 malignant hyperthermia, cerebellar ataxia, atherothrombotic disease)...Clearly, the topic has now become not only very large, but also very stimulating. Its extensive critical coverage is likely to eventually stimulate fruitful interdisciplinary discussions..978-90-481-7560-4978-1-4020-6191-2Series ISSN 0306-0225 Series E-ISSN 2542-8810

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Annexinopathies,e to elevated intracellular calcium. The family members (there are at least 12 in humans) have become specialized over evolutionary time and are involved in a diverse range of cellular functions both inside the cell and extracellularly Although a mutation in an annexin has never been categorically p

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