Titlebook: Calcium Entry Pathways in Non-excitable Cells; Juan A. Rosado Book 2016 The Editor(s) (if applicable) and The Author(s), under exclusive l

Flirtatious

Historical Overview of Store-Operated Ca2+ Entryl members of the TRPC family of channels also take part of the SOC macromolecular complex. This introductory chapter summarizes the early pieces of evidence that led to the concept of SOCE and the components of the store-operated signaling pathway.

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The STIM1: Orai Interactionn the plasmamembrane. The identification of STIM1 and Orai1 and recently the structural resolution of both proteins by X-ray crystallography and nuclear magnetic resonance substantiated many findings from structure-function studies which has substantially improved the understanding of CRAC channel a

冰河期

MIRE

Extracellular Calcium Has Multiple Targets to Control Cell Proliferationas for metabotropic receptors, they not only modulate calcium channel expression but they may also control calcium-dependent K+ channels. The multiplicity of intracellular signaling pathways involved, their sensitivity to local and global intracellular calcium increase and to CaSR and GPRC6a stimula

Defiance

On the Roles of the Transient Receptor Potential Canonical 3 (TRPC3) Channel in Endothelium and MacrPC3 functions to atherogenesis has recently began to receive validation through studies in mouse models of atherosclerosis with conditional gain or loss of TRPC3 function. This chapter summarizes these novel findings and provides a discussion of their impact in the context of atherosclerosis, in an

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Calcium Entry Through Thermosensory Channelsole of Ca. fluxes induced by thermoTRPs on the dynamics of membrane-attached signalling complexes as well as their significance in cellular processes, are central issues that will expand the opportunities for therapeutic intervention in disorders involving dysfunction of thermoTRP channels.

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Intellectual

The Calcium Entry-Calcium Refilling Couplingertaking the whole cell. The coupling between Ca. entry and Ca. refilling can possibly act much further away from the plasma membrane. Ca., uptaken by SERCAs, have been described to move faster and further in the ER than in the cytosol and to create specific signal that depends on Ca. entry but at l

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Role of Scaffolding Proteins in the Regulation of TRPC-Dependent Calcium Entry building of signaling complexes. The scaffolding proteins are involved in the assembling of these Ca. signaling complexes, the correct sub-cellular localization of protein partners, and the regulation of the TRPC channelosome. In particular, these proteins, via their multiple protein–protein intera