Titlebook: Cadmium Interaction with Animal Cells; Frank Thévenod,David Petering,Andrea Hartwig Book 2018 Springer Nature Switzerland AG 2018 Cadmium

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The Chemical Biology of Cadmium,. within the proteome is emphasized. These ideas are given specificity in research into the molecular involvement of Cd. in nephrotoxicity and carcinogenesis. Examples of the chemical participation of Cd. in cell signaling are described. These include the activation of MTF-1 transcription factor and

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Interactions of Cadmium with Signaling Molecules,ometimes be simplified by collecting some of the interactions that have been observed. We discuss some of the general effects of Cd. on cellular Ca. levels, with signaling implications, and also some of the major interactions of Cd. with Ca. binding sites in proteins. A good part of our discussion i

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Cadmium and Its Impact on Genomic Stability,suppressor protein p53. The interaction with critical thiol groups and/or the enhanced generation of ROS may also provoke an interference with cellular redox regulation of critical signaling pathways. Especially the combination of these multiple mechanisms may give rise to a high degree of genomic i

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Don E. Kash,Robin N. Auger,Ning Liby utilizing physiological transport pathways for essential divalent metal ions, such as Fe., Zn., Cu., Ca., or Mn.. ‘Free’ Cd. ions and Cd. ions bound to small organic molecules are transported via ion channels, carrier proteins or ATP hydrolyzing pumps, whereas metalloproteins are internalized by

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